What is a stroke?

A stroke occurs when brain cells die due to a lack of oxygen. This lack of oxygen is caused either by a lack of blood flow to the brain cells (ischemic stroke) or bleeding in or around the brain (hemorrhagic stroke).

Since the brain cells need oxygen-rich blood from the lungs to get oxygen, they will soon start to die when they don’t get enough. As the brain cells die, the person experiences symptoms from the impacted section or sections of the brain.

brain

The exact symptoms of a stroke will depend on its severity and on what or which sections of the brain are impacted. The symptoms appear very suddenly.

Examples of common symptoms of a stroke:

  • Sudden weakness or numbness on one side of the body, e.g, one arm or one leg. Sometimes only one side of the face display symptoms, while the other side is perfectly normal.
  • Sudden dizziness, loss of balance, loss of coordination, and/or trouble walking.
  • Sudden severe headache (a sign of hemorrhagic stroke)
  • Sudden problems seeing (one or both eyes).
  • Sudden confusion, trouble understanding speech and/or difficulty speaking.
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Primary & Secondary Stroke Prevention Framework

Modifiable vascular risk factors, clinical targets, pharmacology, and lifestyle interventions

Risk Factor / Domain Intervention Tier Target Clinical Parameter Mechanisms & Medical Evidence
Hypertension Vascular Sclerosis Leading Modifiable < 130/80 mmHg
(Guideline-directed standard)
Treating elevated blood pressure via ACE inhibitors, ARBs, CCBs, or thiazide diuretics cuts ischemic and hemorrhagic stroke risk by 30%–40%. Mitigates small-vessel lipohyalinosis and microaneurysm rupture.
Atrial Fibrillation Cardioembolic Source Anticoagulation CHA₂DS₂-VASc ≥ 2 (M) / ≥ 3 (F)
DOAC therapy or LAA closure
Stasis in the left atrial appendage triggers dense thrombi that embolize directly into the middle cerebral artery. DOACs (apixaban, rivaroxaban, dabigatran) reduce cardioembolic stroke by ~65% with half the intracranial bleed risk of warfarin.
Hyperlipidemia Large Artery Atherosclerosis Lipid Lowering LDL-C < 70 mg/dL (1.8 mmol/L)
< 55 mg/dL for extreme vascular risk
High-intensity statins (atorvastatin 80 mg) stabilize vulnerable fibrous caps in carotid and vertebral plaques. Adding ezetimibe or PCSK9 inhibitors reduces recurrent ischemic events through plaque regression and anti-inflammatory pleiotropic effects.
Type 2 Diabetes Micro- & Macrovascular Metabolic Control HbA1c < 7.0%
GLP-1 RA / SGLT2i priority
Persistent hyperglycemia accelerates endothelial dysfunction and stiffens arterial walls. GLP-1 receptor agonists (semaglutide, dulaglutide) demonstrate direct anti-atherosclerotic vascular benefits, significantly lowering ischemic stroke endpoints in diabetic cohorts.
Antiplatelet Therapy Non-Cardioembolic Secondary Prevention Aspirin, Clopidogrel, or DAPT
Short-term 21–90 days DAPT post-TIA/minor
Inhibits thromboxane A2 and ADP-mediated platelet aggregation over ruptured atheromas. Dual antiplatelet therapy (aspirin + clopidogrel) initiated within 24 hours of high-risk TIA (ABCD² ≥ 4) or minor stroke markedly prevents early recurrence.
Carotid Artery Stenosis Extracranial Large Vessel Revascularization 70%–99% Stenosis (Symptomatic)
CEA or CAS within 14 days
Carotid endarterectomy (CEA) or carotid artery stenting (CAS) eliminates source plaque in tight ipsilateral stenosis, providing massive relative risk reduction over medical management alone when executed promptly after symptom onset.
Lifestyle Modifiers Behavioral Health Primary Baseline 150 min/wk moderate aerobic exercise
Tobacco cessation; Mediterranean diet
Complete smoking cessation drops vascular risk to near baseline within 5 years. Sodium restriction (< 2.0 g/day) and Mediterranean/DASH nutritional patterns directly attenuate systemic oxidative stress and endothelial inflammation.

Treatment

The treatment after a stroke can be divided into two parts: emergency treatment immediately after the stroke and post-stroke rehabilitation once the person has survived the stroke.

After a stroke, there is an increased risk of another stroke, so diagnosing and treating underlying health conditions and addressing lifestyle factors are also of imperative importance.

Emergency treatment

The exact nature of the emergency treatment after a stroke will depend on the type of stroke. When the stroke is caused by a blood clot, medicine is given to rapidly dissolve the clot. In the case of a hemorrhagic stroke, the bleeding must be stopped and any excess pressure on the brain relieved.

Long-term impact

A stroke can be fatal, and stroke is the 5th most common cause of death in the United States. Of those who survive, two out of three will have some type of long-term disability as a result of the stroke. This disability can for instance be speech problems, hemiplegia, hemiparesis, and/or memory problems. In the United States, stroke is the leading cause of adult disability.

After a stroke, it is not unusual to experience problems with thinking, attention, awareness, judgment, learning, memory, emotion control, forming speech and understanding speech.

Some survivors experience numbness, pain or strange sensations. Pain is especially common in the hands and feet, and there can be a big sensitivity to temperature changes and cold.

What is hemiplegia?

Hemiplegia is the complete paralysis of one side of the body. Hemiplegia can be caused by a stroke.

What is hemiparesis?

Hemiparesis, or unilateral paresis, is a weakness of one entire side of the body. It is less severe than hemiplegia. Hemiparesis can be caused by a stroke.

Epidemiology

  • Data from 2011 show that stroke was the second most common cause of death worldwide. Of all people who died, over 10% died from a stroke.
  • Anyone can suffer a stroke but the risk is higher in people with high pressure (stress) careers.  Stockbrokers, CFD traders, day traders, Forex traders and hedge fund managers are all examples of professions that increase the risk of suffering a stroke. Read more about other lifestyle factors that increase the risk of a stroke.
  • Between 1990 and 2010, the number of strokes decreased by approximately 10% in the developed world. During the same time period, the number of strokes in the developing world increased by 10%.
  • A stroke can occur at any age but is more common in the elderly. Globally, 95% of all strokes occur in people aged 45 and older, and about two out of three strokes occur in persons aged over 65. The risk of experiencing a stroke increases exponentially from 30 years of age.
  • Men are 25% more likely to experience a stroke than women. Still, 60% of all stroke deaths occur in women. This is largely because women live longer and stroke deaths are more common in the elderly. There are also certain risk factors for stroke that pertain to women only: pregnancy, childbirth, menopause, and hormone replacement therapy for issues connected to menopause.